Break the cycle of UTIs and vaginal infections
with AZO® Dual Protection
Disruptions in the vaginal microbiota may underlie recurring infections
A healthy vaginal pH supports protective lactobacilli and helps guard against infection, but when that balance is disrupted, the risk of infection increases.1 Common disruptors like stress, menstruation, sex, and antibiotics can upset the microbiota, leaving women more vulnerable to vaginal or urinary infections and recurrence.2-5
While antibiotics can treat the infection, they aren’t designed to restore the protective microbiota.6 A combination of prebiotics and probiotics can help support balance and maintain feminine health.7
Break the cycle. Restore balance.
AZO® Dual Protection is formulated with a unique prebiotic to help guard the urinary tract and fight unfriendly bacteria, plus Intelliflora™ probiotic to help restore the balance of good bacteria and yeast to support vaginal health.*
Ingredient
Function
Dual Protection
Intelliflora™
Probiotic Blend
Reduces Gardnerella
and Candida
Colonization8
Supports
vaginal health
Enhances Intelliflora™ Growth by 4x†
PreforPro®
Phage Blend
Reduces E. coli 9
Supports
urinary health
Enhances Intelliflora™
Growth by 4x†
Ingredient
Intelliflora™
Probiotic Blend
PreforPro®
Phage Blend
Function
Reduces Gardnerella and
Candida Colonization*
Reduces
E. coli9
Dual Protection
Supports
vaginal health
Supports
urinary health
Clinically studied probiotics and prebiotics
for urinary and vaginal health
Four clinical trials demonstrated the safety and effectiveness of oral supplementation with the Intelliflora™ blend in restoring a healthy vaginal microbiota, balancing yeast and bacteria, and supporting vaginal pH.
Increased
lactobacilli in 7 days
Improved
pH levels
Reduced Candida
& Gardnerella
100% BV clearance with
antibiotics + probiotics
Intelliflora™ blend significantly boosted lactobacilli counts in just 1 week10
Intelliflora™ Blend Results in a Healthy Count of Vaginal Lactobacilli Within 7 Days of Oral Supplementation
There was a significant increase in lactobacilli counts after 7 days of supplementation compared with the placebo group.
More than half of women taking the Intelliflora™ blend restored healthy pH levels8
Intelliflora™ Blend Restores a Healthy Vaginal pH
Women with an abnormal vaginal pH higher than 4.5 saw significant improvement after probiotic supplementation.
Intelliflora™ blend reduced Candida and Gardnerella colonization by up to 50%8
Intelliflora™ Blend Reduced Pathogenic Bacteria and Yeast Colonization
Women with an abnormal vaginal pH higher than 4.5 saw significant improvement after probiotic supplementation.
100% bacterial vaginosis (BV) clearance at 4 weeks with Intelliflora™ blend + antibiotics11
Intelliflora™ Blend Complements Antibiotic Use for Bacterial Vaginosis
At 4 weeks, 100% of women diagnosed with BV and treated with the Intelliflora™ blend plus antibiotics were BV-free compared with 65% in the placebo group.
Phage Prebiotic Blend
for
Urinary Health
Escherichia coli (E. coli), the bacteria responsible for over 90% of urinary tract infections, originate in the intestines and are transmitted via stool to the vaginal and periurethral area. Once in the urinary tract, they can colonize and cause infection.12 PreforPro® phage blend has been shown to selectively target E. coli and reduce populations of the undesirable bacteria.
Significant reduction in E. coli levels with phage prebiotic blend9
Reduction in E. coli Levels
In a randomized, double-blind, placebo-controlled study, PreforPro® phage blend significantly reduced E. coli levels in participants with baseline colonization (p = 0.02), while no significant change was observed with placebo (p = 0.78).
Probiotic proliferation with phage prebiotic blend
In a preclinical study, the PreforPro® phage blend reduced intestinal E. coli levels by 10- to 1,000-fold within 24 hours, while increasing probiotic populations by 10- to 100-fold.13 Within just 5 hours, the PreforPro® phage blend enhanced the growth of the Intelliflora™ probiotic blend by approximately 4-fold compared with Intelliflora™ probiotic blend alone.13,†‡
Ready to help your patients break the cycle of recurrent UTIs and vaginal infections?
Recommend AZO® Dual Protection—a safe, effective option for restoring balance and maintaining urinary and vaginal health.*
REQUEST COUPONSBy clicking Request Coupons, you're confirming that you agree with our Terms and Conditions.
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
†Results based on an in vitro study.
‡This testing occurred under conditions of the human intestine and included E. coli isolated from patients with UTI.
References:
- Stapleton AE. The vaginal microbiota and urinary tract infection. Microbiol Spectr. 2016;4(6):10.1128/microbiolspec.UTI-0025-2016. doi:10.1128/microbiolspec.UTI-0025-2016
- Amabebe E, Anumba DOC. Psychosocial stress, cortisol levels, and maintenance of vaginal health. Front Endocrinol (Lausanne). 2018;9:568. doi:10.3389/fendo.2018.00568
- Hugerth LW, Krog MC, Vomstein K, et al. Defining vaginal community dynamics: daily microbiome transitions, the role of menstruation, bacteriophages, and bacterial genes. Microbiome. 2024;12(1):153. doi:10.1186/s40168-024-01870-5
- Ratten LK, Plummer EL, Murray GL, et al. Sex is associated with the persistence of non-optimal vaginal microbiota following treatment for bacterial vaginosis: a prospective cohort study. BJOG. 2021;128(4):756-767. doi:10.1111/1471-0528.16430
- Mayer BT, Srinivasan S, Fiedler TL, Marrazzo JM, Fredricks DN, Schiffer JT. Rapid and profound shifts in the vaginal microbiota following antibiotic treatment for bacterial vaginosis. J Infect Dis. 2015;212(5):793-802. doi:10.1093/infdis/jiv079
- Lachyan A, Khunger N, Panda PS. Bacterial vaginosis and biofilms: therapeutic challenges and innovations – a narrative review. Indian J Dermatol Venereol Leprol. 2024;90(6):750-754. doi:10.25259/IJDVL_1322_2023
- Pagar RR, Deshkar S, Mahore J, et al. The microbial revolution: unveiling the benefits of vaginal probiotics and prebiotics. Microbiol Res. 2024;286:127787. doi:10.1016/j.micres.2024.127787
- Anoshina TM. Role of microbiota correction in complex treatment of pregnant women with herpesvirus infection [Роль корекції мікробіоти у комплексному лікуванні вагітних з герпесвірусною інфекцією]. Perinatol i Pediatr. 2016;4(68):22-25. doi:10.15574/PP.2016.68.22
- Febvre HP, Rao S, Gindin M, et al. PHAGE study: effects of supplemental bacteriophage intake on inflammation and gut microbiota in healthy adults. Nutrients. 2019;11(3):666. doi:10.3390/nu11030666
- Kaufmann U, Domig KJ, Lippitsch CI, et al. Ability of an orally administered lactobacilli preparation to improve the quality of the neovaginal microflora in male to female transsexual women. Eur J Obstet Gynecol Reprod Biol. 2014;172:102-105. doi:10.1016/j.ejogrb.2013.10.019
- Laue C, Papazova E, Liesegang A, et al. Effect of a yoghurt drink containing Lactobacillus strains on bacterial vaginosis in women - a double-blind, randomised, controlled clinical pilot trial. Benef Microbes. 2018;9(1):35-50. doi:10.3920/BM2017.0018
- Katouli M. Population structure of gut Escherichia coli and its role in development of extra‑intestinal infections. Iran J Microbiol. 2010;2(2):59-72.
- Data on file.